Description
Product Characteristics:
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Subcellular location: Extracellular matrix
Synonyms: Hemofiltrate peptide HF7665, ISK5_HUMAN, LEKTI, Lympho-epithelial Kazal-type-related inhibitor, Lymphoepithelial Kazal type related inhibitor, NETS, NS, Serine peptidase inhibitor Kazal type 5, SPINK5, VAKTI.
Target Information: This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene